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Article

Negative charges at protein kinase C sites of troponin I stabilize the inactive state of actin.

Biophysical journal - 15 Jan 2008

Mathur Mohit C, Kobayashi Tomoyoshi, Chalovich Joseph M

Abstract excerpt

Alterations in the troponin complex can lead to increases or decreases in contractile activity. Most mutations of troponin that cause hypertrophic cardiomyopathy increase the activity of cardiac muscle fibers. In at least some cases these mutants stabilize the active state of regulated actin. In...

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Identifiers

PMID: 17872964
DOI: 10.1529/biophysj.107.113944
PMCID: PMC2157249

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17872964-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Negative charges at protein kinase C sites of troponin I stabilize the inactive state of actin.PMID 17872964Read ↗

Troponin C Mutations Partially Stabilize the Active State of Regulated Actin and Fully Stabilize the Active State When Paired with Δ14 TnT.Semantic proximity Read ↗

Some cardiomyopathy-causing troponin I mutations stabilize a functional intermediate actin state.Semantic proximity Read ↗

Several cardiomyopathy causing mutations on tropomyosin either destabilize the active state of actomyosin or alter the binding properties of tropomyosin.Semantic proximity Read ↗

Stepwise C-Terminal Truncation of Cardiac Troponin T Alters Function at Low and Saturating Ca <sup>2+</sup>Semantic proximity Read ↗

Basic residues within the cardiac troponin T C terminus are required for full inhibition of muscle contraction and limit activation by calcium.Semantic proximity Read ↗

The Delta 14 mutation of human cardiac troponin T enhances ATPase activity and alters the cooperative binding of S1-ADP to regulated actin.Semantic proximity Read ↗

The Cardiomyopathy Mutation, R146G Troponin I, Stabilizes the Intermediate "C" State of Regulated Actin under High- and Low-Free Ca(2+) Conditions.Semantic proximity Read ↗

Mutations in human cardiac troponin I that are associated with restrictive cardiomyopathy affect basal ATPase activity and the calcium sensitivity of force development.Semantic proximity Read ↗

Alterations in thin filament regulation induced by a human cardiac troponin T mutant that causes dilated cardiomyopathy are distinct from those induced by troponin T mutants that cause hypertrophic cardiomyopathy.Semantic proximity Read ↗

Disease causing mutations of troponin alter regulated actin state distributions.Semantic proximity Read ↗

Two mutations in troponin I that cause hypertrophic cardiomyopathy have contrasting effects on cardiac muscle contractility.Semantic proximity Read ↗

New insights into the functional significance of the acidic region of the unique N-terminal extension of cardiac troponin I.Semantic proximity Read ↗

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