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Article

The Delta 14 mutation of human cardiac troponin T enhances ATPase activity and alters the cooperative binding of S1-ADP to regulated actin.

Biochemistry - 7 Dec 2004

Gafurov Boris, Fredricksen Scott, Cai Anmei, Brenner Bernhard, Chase P Bryant, Chalovich Joseph M

Abstract excerpt

The complex of tropomyosin and troponin binds to actin and inhibits activation of myosin ATPase activity and force production of striated muscles at low free Ca(2+) concentrations. Ca(2+) stimulates ATP activity, and at subsaturating actin concentrations, the binding of NEM-modified S1 to actin-tropomyosin-troponin increases the rate of ATP hydrolysis even further. We show here that the Delta14 mutation of...

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Identifiers

PMID: 15568820
DOI: 10.1021/bi048646h
PMCID: PMC1351011

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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