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Article

Neutralization of soluble, synaptotoxic amyloid β species by antibodies is epitope specific.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 22 Feb 2012

Zago Wagner, Buttini Manuel, Comery Thomas A, Nishioka Christopher, Gardai Shyra J, Seubert Peter, Games Dora, Bard Frédérique, Schenk Dale, Kinney Gene G

Abstract excerpt

Several anti-amyloid β (Aβ) antibodies are under evaluation for the treatment of Alzheimer's disease (AD). Clinical studies using the N-terminal-directed anti-Aβ antibody bapineuzumab have demonstrated reduced brain PET-Pittsburg-B signals, suggesting the reduction of Aβ plaques, and reduced levels of total and phosphorylated tau protein in the CSF of treated AD patients. Preclinical studies using 3D6 (the murine...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22357853
DOI: 10.1523/JNEUROSCI.1676-11.2012
PMCID: PMC6621896

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APP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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