Article

A standardized toolkit for programmable protein secretion and surface display in <i>Bacteroides thetaiotaomicron</i>

2026-05-14

Abstract excerpt

Bacteroides thetaiotaomicron ( Bt ), a dominant bacterial species in the human gut, is a promising chassis for engineering in situ therapeutic delivery systems. Previously, we developed a secretion toolkit composed of endogenous lipoprotein signal peptides (SPs) and full-length secretory proteins from Bt . However, due to variations in length, structure, and amino-acid sequence, these SPs exhibited inconsistent...

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Literature Corpus work: 1e3ae309-11e1-5896-bff3-7a0a38383ec7
DOI: 10.64898/2026.05.12.724727

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