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Article

TOR signaling regulates liquid phase separation of the SMN complex governing snRNP biogenesis.

Cell reports - 22 Jun 2021

Schilling Maximilian, Prusty Archana B, Boysen Björn, Oppermann Felix S, Riedel Yannick L, Husedzinovic Alma, Rasouli Homa, König Angelika, Ramanathan Pradhipa, Reymann Jürgen, Erfle Holger, Daub Henrik, Fischer Utz, Gruss Oliver J

Abstract excerpt

The activity of the SMN complex in promoting the assembly of pre-mRNA processing UsnRNPs correlates with condensation of the complex in nuclear Cajal bodies. While mechanistic details of its activity have been elucidated, the molecular basis for condensation remains unclear. High SMN complex phosphorylation suggests extensive regulation. Here, we report on systematic siRNA-based screening for modulators of the...

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Identifiers

PMID: 34161763
DOI: 10.1016/j.celrep.2021.109277

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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