Article

SEMA4D upregulation signals neuronal stress and triggers reactive transformation of astrocytes

2021-01-19

Abstract excerpt

The close interaction and interdependence of glial cells and neurons allows for the possibility that glial dysfunction contributes to and amplifies neurodegenerative pathology. Drivers of glial cell activation may represent important targets to preserve normal homeostatic maintenance and modify disease progression. We report here that semaphorin 4D (SEMA4D) is a trigger of astrocyte activation and is upregulated i...

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Literature Corpus work: a352a4bb-bc0e-5839-9df2-b75b3acd7b3b
DOI: 10.21203/rs.3.rs-62001/v1

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