Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Origins of Gastric Cancer From Gastric Stem Cells: Lessons From Mouse Models

21 Feb 2017

Abstract excerpt

The cellular origin of digestive cancers has been a long-standing question in the cancer field. Mouse models have identified long-lived stem cells in most organ systems, including the luminal gastrointestinal tract, and numerous studies have pointed to tissue resident stem cells as the main cellular origin of cancer. During gastric carcinogenesis, chronic inflammation induces genetic and epigenetic alterations in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Cells and Metastasis
Share to Cancer Research and Treatments
Share to Digestive system and related health

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 28462375
DOI: 10.1016/j.jcmgh.2017.01.013

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Origins of Gastric Cancer From Gastric Stem Cells: Lessons From Mouse ModelsPMID 28462375Read ↗

Stem Cells, Helicobacter pylori, and Mutational Landscape: Utility of Preclinical Models to Understand Carcinogenesis and to Direct Management of Gastric Cancer.Semantic proximity Read ↗

Stem cells in gastric cancer.Semantic proximity Read ↗

Gastric Stem Cells: Physiological and Pathological PerspectivesSemantic proximity Read ↗

Gastric stem cells and gastric cancer stem cellsSemantic proximity Read ↗

Stem Cell Biomarkers and Tumorigenesis in Gastric CancerSemantic proximity Read ↗

Notch as a Driver of Gastric Epithelial Cell ProliferationSemantic proximity Read ↗

Stem cell relationships and the origin of gastrointestinal cancer.Semantic proximity Read ↗

Cellular plasticity and fate determination in gastric carcinogenesisSemantic proximity Read ↗

Gastric cancer originating from bone marrow-derived cells.Semantic proximity Read ↗

Cancer stem cell hypothesis and gastric carcinogenesis: Experimental evidence and unsolved questionsSemantic proximity Read ↗

Invasive mouse gastric adenocarcinomas arising from Lgr5+ stem cells are dependent on crosstalk between the Hedgehog/GLI2 and mTOR pathwaysSemantic proximity Read ↗

Initiation and Maintenance of Gastric Cancer: A Focus on CD44 Variant Isoforms and Cancer Stem CellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.