Article
Autism-associated neuroligin-3 mutations commonly impair striatal circuits to boost repetitive behaviors.
Cell - 3 Jul 2014
Rothwell Patrick E, Fuccillo Marc V, Maxeiner Stephan, Hayton Scott J, Gokce Ozgun, Lim Byung Kook, Fowler Stephen C, Malenka Robert C, Südhof Thomas C
Abstract excerpt
In humans, neuroligin-3 mutations are associated with autism, whereas in mice, the corresponding mutations produce robust synaptic and behavioral changes. However, different neuroligin-3 mutations cause largely distinct phenotypes in mice, and no causal relationship links a specific synaptic dysfunction to a behavioral change. Using rotarod motor learning as a proxy for acquired repetitive behaviors in mice, we...
Topics
- Animals
- Autistic Disorder
- Basal Ganglia
- Cell Adhesion Molecules, Neuronal
- Humans
- Membrane Proteins
- Mice
- Mice, Knockout
- Mutation
- Nerve Tissue Proteins
- Nucleus Accumbens