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Article

Gene alterations in inborn errors of immunity and their presence in cancers: Implications for oncogenesis, progression, and outcomes.

Human immunology - 1 Mar 2026

Lokanc Samuel, Sipila Patrick, Cuvelier Geoffrey D E, Murguía-Favela Luis, Wright Nicola Am, Grunebaum Eyal, Bose Pinaki, Narendran Aru

Abstract excerpt

Inborn Errors of Immunity (IEI) are genetic disorders impairing the immune system, increasing susceptibility to infections, autoimmunity, inflammation, and malignancies. Mutations in over 500 genes have been shown to cause IEI. This study investigated IEI-related differential gene expression by examining the somatic transcriptomes of cancers. RNA-sequencing data from cancers were obtained from TCGA and TARGET...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 41616493
DOI: 10.1016/j.humimm.2026.111671

Genes

CFH
ANGPT1
CFB
CFD
CR2
F5
SEMA3E
TMPRSS15

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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