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Article

Complement is increased in treatment resistant rectal cancer and modulates radioresistance

14 Sept 2024

Abstract excerpt

Resistance to neoadjuvant chemoradiation therapy (neo-CRT) is a significant clinical problem in the treatment of locally advanced rectal cancer. Identification of novel therapeutic targets and biomarkers predicting therapeutic response is required to improve patient outcomes. Increasing evidence supports a role for the complement system in resistance to anti-cancer therapy. In this study, increased expression of...

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PMID: 39278399
DOI: 10.1016/j.canlet.2024.217253

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