Article

Identification of a SARS-CoV-2 host metalloproteinase-dependent entry pathway differentially used by SARS-CoV-2 and variants of concern Alpha, Delta, and Omicron

2022-02-22

Abstract excerpt

<h4>ABSTRACT</h4> To infect cells, severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) binds to angiotensin converting enzyme 2 (ACE2) via its spike glycoprotein (S), delivering its genome upon S-mediated membrane fusion. SARS-CoV-2 uses two distinct entry pathways: 1) a surface, serine protease-dependent or 2) an endosomal, cysteine protease-dependent pathway. In investigating serine protease-independen...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a7b987b5-fc40-54e2-9c35-c6a4e39949cf
DOI: 10.1101/2022.02.19.481107

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Identification of a SARS-CoV-2 host metalloproteinase-dependent entry pathway differentially used by SARS-CoV-2 and variants of concern Alpha, Delta, and OmicronDOI 10.1101/2022.02.19.481107Read

Metalloproteinase-dependent and TMPRSS2-independnt cell surface entry pathway of SARS-CoV-2 requires the furin-cleavage site and the S2 domain of spike proteinSemantic proximity Read

A disintegrin and metalloproteinase domain 9 facilitates SARS-CoV-2 entry into cells with low ACE2 expressionSemantic proximity Read

Control of SARS-CoV-2 infection by MT1-MMP-mediated shedding of ACE2Semantic proximity Read

SARS-CoV-2 and SARS-CoV spike-mediated cell-cell fusion differ in the requirements for receptor expression and proteolytic activationSemantic proximity Read

SARS-CoV-2 Omicron spike H655Y mutation is responsible for enhancement of the endosomal entry pathway and reduction of cell surface entry pathwaysSemantic proximity Read

TMPRSS11D and TMPRSS13 Activate the SARS-CoV-2 Spike ProteinSemantic proximity Read

Distinctive Roles of Furin and TMPRSS2 in SARS-CoV-2 InfectivitySemantic proximity Read

ADAM10 and ADAM17 promote SARS‐CoV‐2 cell entry and spike protein‐mediated lung cell fusionSemantic proximity Read

SARS-CoV-2 variants with mutations at the S1/S2 cleavage site are generated <i>in vitro</i> during propagation in TMPRSS2-deficient cellsSemantic proximity Read

Acquisition of Furin Cleavage Site and Further SARS-CoV-2 Evolution Change the Mechanisms of Viral Entry, Infection Spread, and Cell SignalingSemantic proximity Read

Genome-wide Bioinformatics Analysis of Human Protease Specificity Identified Potential Cathepsin L Cleavage Site at K790 Position of the SARS-CoV-2 Spike GlycoproteinSemantic proximity Read

Proteolytic activation of SARS-CoV-2 spike at the S1/S2 boundary: potential role of proteases beyond furinSemantic proximity Read