Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

ACE2-Independent Bat Sarbecovirus Entry and Replication in Human and Bat Cells

21 Nov 2022

Abstract excerpt

Our studies demonstrate that some unexplored sarbecoviruses are capable of replicating in human and bat cells in an ACE2-independent way but need a high trypsin environment. We found that trypsin is not compensated by other known proteases involved in some coronavirus entry. This work provides important information that the trypsin-dependent entry may be a widely employed mechanism for coronaviruses and will help...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Animal Virus Infections Studies
Share to SARS-CoV-2 and COVID-19 Research
Share to Virus-based gene therapy research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 36409074
DOI: 10.1128/mbio.02566-22

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

ACE2-Independent Bat Sarbecovirus Entry and Replication in Human and Bat CellsPMID 36409074Read ↗

Species-Specific Molecular Barriers to SARS-CoV-2 Replication in Bat CellsSemantic proximity Read ↗

Bat-infecting merbecovirus HKU5-CoV lineage 2 can use human ACE2 as a cell entry receptorSemantic proximity Read ↗

Trypsin Enhances SARS-CoV-2 Infection by Facilitating Viral EntrySemantic proximity Read ↗

Cathepsins in cellular entry of human pathogenic virusesSemantic proximity Read ↗

Host cell proteases: Critical determinants of coronavirus tropism and pathogenesisSemantic proximity Read ↗

Coronaviruses with a SARS-CoV-2-like receptor-binding domain allowing ACE2-mediated entry into human cells isolated from bats of Indochinese peninsulaSemantic proximity Read ↗

Broad host tropism of ACE2-using MERS-related coronaviruses and determinants restricting viral recognitionSemantic proximity Read ↗

Host Cell Proteases Involved in Human Respiratory Viral Infections and Their Inhibitors: A ReviewSemantic proximity Read ↗

Species-specific molecular barriers to SARS-CoV-2 replication in bat cellsSemantic proximity Read ↗

The respective roles of TMPRSS2 and cathepsins for SARS-CoV-2 infection in human respiratory organoidsSemantic proximity Read ↗

Human Coronavirus EMC Does Not Require the SARS-Coronavirus Receptor and Maintains Broad Replicative Capability in Mammalian Cell LinesSemantic proximity Read ↗

Human airway cells prevent SARS-CoV-2 multibasic cleavage site cell culture adaptationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.