Article

Sex-Specific Differential DNA Methylation in Mild Cognitive Impairment and Alzheimer’s Disease

2025-05-19

Abstract excerpt

Sex differences in late-onset Alzheimer’s disease (AD) progression include accelerated decrements in cognitive status and greater amyloid and tau biomarker burdens in females. To identify sex-specific differentially methylated positions (DMPs) and genes in persons with mild cognitive impairment (MCI) and AD, we analyzed whole genome methylation sequencing on blood samples from participants with MCI (N=99, 52% fema...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1dbd3f1b-f588-53f3-93aa-1cad834c5fba
DOI: 10.1101/2025.05.15.654279

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Sex-Specific Differential DNA Methylation in Mild Cognitive Impairment and Alzheimer’s DiseaseDOI 10.1101/2025.05.15.654279Read

Distinct sex-specific DNA methylation differences in Alzheimer’s diseaseSemantic proximity Read

Sex-specific DNA methylation differences in Alzheimer’s disease pathologySemantic proximity Read

Sex-specific DNA methylation changes in Alzheimer’s disease pathologySemantic proximity Read

Sex-specific DNA methylation changes in Alzheimer’s disease pathologySemantic proximity Read

Whole genome methylation sequencing in blood from persons with mild cognitive impairment and dementia due to Alzheimer's disease identifies cognitive statusSemantic proximity Read

Whole genome methylation sequencing in blood from persons with mild cognitive impairment and dementia due to Alzheimer’s disease identifies cognitive statusSemantic proximity Read

Whole genome methylation sequencing in blood identifies extensive differential DNA methylation in late‐onset dementia due to Alzheimer's diseaseSemantic proximity Read

Epigenetic genes are differentially methylated in the blood of persons with mild cognitive impairment and Alzheimer’s diseaseSemantic proximity Read

Sex-specific Associations of Gene Expression with Alzheimer’s Disease Neuropathology and Ante-mortem Cognitive PerformanceSemantic proximity Read

Sex-specific Associations of Gene Expression with Alzheimer’s Disease Neuropathology and Ante-mortem Cognitive PerformanceSemantic proximity Read

Genome-wide analysis of genetic predisposition to Alzheimer’s disease and related sex-disparitiesSemantic proximity Read

APOE genotype-specific methylation patterns are linked to Alzheimer disease pathology and estrogen response.Semantic proximity Read