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Bidirectional Mendelian Randomization and Multiphenotype GWAS Show Causality and Shared Pathophysiology Between Depression and Type 2 Diabetes.

Diabetes care - 1 Sept 2023

Maina Jared G, Balkhiyarova Zhanna, Nouwen Arie, Pupko Igor, Ulrich Anna, Boissel Mathilde, Bonnefond Amélie, Froguel Philippe, Khamis Amna, Prokopenko Inga, Kaakinen Marika

Abstract excerpt

OBJECTIVE: Depression is a common comorbidity of type 2 diabetes. We assessed the causal relationships and shared genetics between them. RESEARCH DESIGN AND METHODS: We applied two-sample, bidirectional Mendelian randomization (MR) to assess causality between type 2 diabetes and depression. We investigated potential mediation using two-step MR. To identify shared genetics, we performed 1) genome-wide association...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37494602
DOI: 10.2337/dc22-2373
PMCID: PMC10465984

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