Article
Variation among intact tissue samples reveals the core transcriptional features of human CNS cell classes
2018-02-14
Abstract excerpt
It is widely assumed that cells must be physically isolated to study their molecular profiles. However, intact tissue samples naturally exhibit variation in cellular composition, which drives covariation of cell-class-specific molecular features. By analyzing transcriptional covariation in 7221 intact CNS samples from 840 individuals representing billions of cells, we reveal the core transcriptional identities of...
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Identifiers and source
- Literature Corpus work
- 1d9203ea-f4a9-5b61-8154-5bdbd93536f0
- DOI
- 10.1101/265397