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Article

α-Synuclein Gene May Interact with Environmental Factors in Increasing Risk of Parkinson’s Disease

1 Jan 2010

Abstract excerpt

BACKGROUND: Although of great interest and suggested in prior reports, possible α-synuclein (SNCA) gene-environment interactions have not been well investigated in humans. METHODS: We used a population-based approach to examine whether the risk of Parkinson's disease (PD) depended on the combined presence of SNCA variations and two important environmental factors, pesticide exposures and smoking....

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PMID: 20664293
DOI: 10.1159/000315157

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