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Article

Association between gene polymorphism and depression in Parkinson's disease: A case-control study.

Journal of the neurological sciences - 15 Apr 2017

Zheng Jinhua, Yang Xinglong, Zhao Quanzhen, Tian Sijia, Huang Hongyan, Chen Yalan, Xu Yanming

Abstract excerpt

OBJECTIVE: To investigate possible associations of Parkinson's disease (PD) with polymorphism in depression-related genes and in the alpha-synuclein (SNCA) gene. METHODS: A consecutive series of patients with PD were divided into those with depression and those without it. Patients (330) were genotyped at four single-nucleotide polymorphisms (SNPs) in four genes previously associated with depression, as well as...

Topics

Aged
Amino Acid Transport Systems, Neutral
Asian People
Basic-Leucine Zipper Transcription Factors
Case-Control Studies
Depression
Female
Gene Frequency
Genetic Association Studies
Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genotype

Humans

Logistic Models

Male

Middle Aged

Nerve Tissue Proteins

Parkinson Disease

Polymorphism, Single Nucleotide

Source

Identifiers

PMID: 28320136
DOI: 10.1016/j.jns.2017.02.001

Genes

SNCA
TPH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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