Article
Familial α-synucleinopathy spectrum features in patients with psychiatric REM sleep behaviour disorder.
Journal of neurology, neurosurgery, and psychiatry - 1 Nov 2023
Wang Jing, Lam Siu Ping, Huang Bei, Liu Yaping, Zhang Jihui, Yu Mandy W M, Tsang Jessie C C, Zhou Li, Chau Steven W H, Chan Ngan Yin, Chan Joey W Y, Schenck Carlos H, Li Shirley X, Mok Vincent C T, Ma Karen Ka Yan, Chan Anne Yin Yan, Wing Yun Kwok
Abstract excerpt
BACKGROUND: Rapid eye movement (REM) sleep behaviour disorder (RBD) is one of the earliest and most specific prodromes of the α-synucleinopathies including Parkinson's disease (PD). It remains uncertain whether RBD occurring in the context of psychiatric disorders (psy-RBD), although very common, is merely a benign epiphenomenon of antidepressant treatment, or whether it harbours an underlying α-synucleinopathy....
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