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Age-Environment and Gene-Environment Interactions in the Pathogenesis of Parkinson's Disease

1 Jan 2002

Abstract excerpt

Parkinson's disease (PD) is a common neurodegenerative disease characterized by dopaminergic cell death and deposition of Lewy bodies within the substantia nigra of the midbrain. Although the major risk factors for PD are aging and environmental factors, there is an important genetic component. An age-related change in xenobiotic metabolism alters the metabolism of and net exposure to, environmental neurotoxins....

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Identifiers

PMID: 12088093
DOI: 10.1515/reveh.2002.17.1.51

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