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Article

Impact of non-genetic heterogeneity of BRAF-mutant colon cancer organoids on growth kinetics, drug sensitivity and Wnt dynamics.

International journal of cancer - 15 Jul 2026

Zieger Viktoria, Woehr Ellen, Traichel Jasmin, Brummer Tilman, Zengerle Roland, Kartmann Sabrina, Zimmermann Stefan

Abstract excerpt

Patient-derived organoid (PDO) models are powerful systems for studying tumor biology and drug response. By retaining genetic, histological, and functional characteristics of the original tumor, including intra- and interpatient heterogeneity, they provide powerful tools to investigate therapy resistance. While genomic profiling is well established in organoid-based screening, non-genetic parameters such as...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Proto-Oncogene Proteins B-raf

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Source

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Identifiers

PMID: 41833556
DOI: 10.1002/ijc.70453
PMCID: PMC13193477

Genes

BRAF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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