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Article

Regulation of Inflammatory Response by Transmembrane Adaptor Protein LST1.

Frontiers in immunology - 1 Jan 2021

Fabisik Matej, Tureckova Jolana, Pavliuchenko Nataliia, Kralova Jarmila, Balounova Jana, Vicikova Kristina, Skopcova Tereza, Spoutil Frantisek, Pokorna Jana, Angelisova Pavla, Malissen Bernard, Prochazka Jan, Sedlacek Radislav, Brdicka Tomas

Abstract excerpt

LST1 is a small adaptor protein expressed in leukocytes of myeloid lineage. Due to the binding to protein tyrosine phosphatases SHP1 and SHP2 it was thought to have negative regulatory function in leukocyte signaling. It was also shown to be involved in cytoskeleton regulation and generation of tunneling nanotubes. LST1 gene is located in MHCIII locus close to many immunologically relevant genes. In addition, its...

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Identifiers

PMID: 33986741
DOI: 10.3389/fimmu.2021.618332
PMCID: PMC8111073

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