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Fragile X mental retardation protein coordinates neuron-to-glia communication for clearance of developmentally transient brain neurons

15 Mar 2023

Abstract excerpt

In the developmental remodeling of brain circuits, neurons are removed by glial phagocytosis to optimize adult behavior. Fragile X mental retardation protein (FMRP) regulates neuron-to-glia signaling to drive glial phagocytosis for targeted neuron pruning. We find that FMRP acts in a mothers against decapentaplegic (Mad)-insulin receptor (InR)-protein kinase B (Akt) pathway to regulate pretaporter (Prtp) and...

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PMID: 36920921
DOI: 10.1073/pnas.2216887120

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