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Article

Toll-like receptor 1 variations influence susceptibility and immune response to Mycobacterium tuberculosis.

Tuberculosis (Edinburgh, Scotland) - 1 May 2015

Dittrich Nickel, Berrocal-Almanza Luis C, Thada Shruthi, Goyal Surabhi, Slevogt Hortense, Sumanlatha Gaddam, Hussain Abid, Sur Saubashya, Burkert Sanne, Oh Djin-Ye, Valluri Vijayalakshmi, Schumann Ralf R, Conrad Melanie L

Abstract excerpt

BACKGROUND: Tuberculosis (TB), a disease caused by Mycobacterium tuberculosis (MTB) infection, is still a global public health problem. TB susceptibility varies greatly in infected individuals, and mycobacterial recognition by the innate immune system likely affects disease course and outcome. This research describes a single nucleotide polymorphism in the Toll-like receptor (TLR) 1 gene that functionally alters...

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Source

Identifiers

PMID: 25857934
DOI: 10.1016/j.tube.2015.02.045

Genes

TLR1
TNF
TLR2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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