Article
Genetic association and expression studies indicate a role of toll-like receptor 8 in pulmonary tuberculosis.
PLoS genetics - 1 Oct 2008
Davila Sonia, Hibberd Martin L, Hari Dass Ranjeeta, Wong Hazel E E, Sahiratmadja Edhyana, Bonnard Carine, Alisjahbana Bachti, Szeszko Jeffrey S, Balabanova Yanina, Drobniewski Francis, van Crevel Reinout, van de Vosse Esther, Nejentsev Sergey, Ottenhoff Tom H M, Seielstad Mark
Abstract excerpt
Despite high rates of exposure, only 5-10% of people infected with Mycobacterium tuberculosis will develop active tuberculosis (TB) disease, suggesting a significant role for genetic variation in the human immune response to this infection. Here, we studied TB association and expression of 18 genes involved in the Toll-like receptor (TLR) pathways. Initially, we genotyped 149 sequence polymorphisms in 375...
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