Article

Squamous trans-differentiation of pancreatic cancer cells promotes stromal inflammation

2019-11-06

Abstract excerpt

A highly aggressive subset of pancreatic ductal adenocarcinomas undergo trans-differentiation into the squamous lineage during disease progression. While the tumorigenic consequences of this aberrant cell fate transition are poorly understood, recent studies have identified a role for the master regulator TP63 in this process. Here, we investigated whether squamous trans-differentiation of pancreatic cancer cells...

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Literature Corpus work: 1d41aa14-2177-57d1-ab08-1aa1d5682d24
DOI: 10.1101/833046

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