Characterization of tumor-derived pancreatic stellate cells.

doi:10.1016/j.jss.2009.03.064

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Article

Characterization of tumor-derived pancreatic stellate cells.

The Journal of surgical research - 1 Nov 2009

Farrow Buckminster, Rowley David, Dang Truong, Berger David H

Abstract excerpt

BACKGROUND: Pancreatic stellate cells (PSCs) are key mediators of the desmoplastic reaction that characterizes pancreatic adenocarcinoma. We sought to isolate and characterize tumor-derived pancreatic stellate (TDPS) cells to further understand how these stromal cells influence pancreatic cancer behavior. METHODS: We established a stable line of non-immortalized PSCs from a patient with pancreatic adenocarcinoma...

Topics

Actins
Adenocarcinoma
Cell Communication
Cell Culture Techniques
Fibroblasts
Gene Expression Regulation, Neoplastic
Humans
Keratins
Oligonucleotide Array Sequence Analysis
Pancreatic Neoplasms
Phenotype
Stromal Cells
Tumor Cells, Cultured
Vimentin

Source

Open in PubMed

Identifiers

PMID: 19726060
DOI: 10.1016/j.jss.2009.03.064

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