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Article

Toll-like receptor 4 signaling in osteoblasts is required for load-induced bone formation in mice

2022-08-05

Abstract excerpt

<h4>ABSTRACT</h4> During skeletal development, expression of nerve growth factor (NGF) leads to the survival of afferent sensory nerves that express neurotrophic tyrosine kinase receptor type 1 (TrkA), the high affinity receptor for NGF. In adulthood, NGF is expressed by mature osteoblasts following mechanical loading and signals through TrkA receptors in resident sensory nerves to support load-induced bone forma...

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Literature Corpus work
e0486e3d-1d9c-5784-a5d7-ebff3643ebe4
DOI
10.1101/2022.08.05.502963
Open publication

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Toll-like receptor 4 signaling in osteoblasts is required for load-induced bone formation in miceDOI 10.1101/2022.08.05.502963
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