Article

A cholesterol-coupled N-acetyl-aspartyl-glutamate metabolic network facilitates the neuroprotective impact of estradiol in neurons

2024-06-10

Abstract excerpt

<title>Abstract</title> <p>Sex differences have been demonstrated in Alzheimer's disease (AD), yet the intrinsic cellular changes underlying the enhanced disease vulnerability observed in postmenopausal women remain elusive. We demonstrate that sustained loss of peripheral estradiol is correlated with accelerated cognitive and memory decline. The resulting brain transcriptomic and metabolomic changes suggest the...

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Literature Corpus work: aab44220-21c5-5297-879b-b0b06b11680c
DOI: 10.21203/rs.3.rs-4489289/v1

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A cholesterol-coupled N-acetyl-aspartyl-glutamate metabolic network facilitates the neuroprotective impact of estradiol in neuronsDOI 10.21203/rs.3.rs-4489289/v1Read

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