Article
Intrahepatic cholestasis of pregnancy levels of sulfated progesterone metabolites inhibit farnesoid X receptor resulting in a cholestatic phenotype.
Hepatology (Baltimore, Md.) - 1 Feb 2013
Abu-Hayyeh Shadi, Papacleovoulou Georgia, Lövgren-Sandblom Anita, Tahir Mehreen, Oduwole Olayiwola, Jamaludin Nurul Akmal, Ravat Sabiha, Nikolova Vanya, Chambers Jenny, Selden Clare, Rees Myrddin, Marschall Hanns-Ulrich, Parker Malcolm G, Williamson Catherine
Abstract excerpt
UNLABELLED: Intrahepatic cholestasis of pregnancy (ICP) is the most prevalent pregnancy-specific liver disease and is associated with an increased risk of adverse fetal outcomes, including preterm labor and intrauterine death. The endocrine signals that cause cholestasis are not known but 3α-sulfated progesterone metabolites have been shown to be elevated in ICP, leading us to study the impact of sulfated...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.