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Article

Promoter DNA methylation of farnesoid X receptor and pregnane X receptor modulates the intrahepatic cholestasis of pregnancy phenotype.

PloS one - 1 Jan 2014

Cabrerizo Romina, Castaño Gustavo O, Burgueño Adriana L, Fernández Gianotti Tomas, Gonzalez Lopez Ledesma María Mora, Flichman Diego, Pirola Carlos J, Sookoian Silvia

Abstract excerpt

The intrahepatic cholestasis of pregnancy (ICP) is a multifactorial liver disorder which pathogenesis involves the interplay among abnormal bile acid (BA) levels, sex hormones, environmental factors, and genetic susceptibility. The dynamic nature of ICP that usually resolves soon after delivery suggests the possibility that its pathobiology is under epigenetic modulation. We explored the status of white blood...

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Share to Cholestasis, Intrahepatic
Share to Constitutive Androstane Receptor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Methylation

Share to Epigenesis, Genetic

Share to Multidrug Resistance-Associated Protein 2

Share to Pregnancy

Share to Pregnancy Complications

Share to Receptors, Cytoplasmic and Nuclear

Source

Open in PubMed Open full text

Identifiers

PMID: 24498169
DOI: 10.1371/journal.pone.0087697
PMCID: PMC3909199

Genes

ABCC2
ESR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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