Article

1-Methyl-D-tryptophan activates aryl hydrocarbon receptor, a pathway associated with bladder cancer progression

2020-09-02

Abstract excerpt

<title>Abstract</title> <p><bold>Background</bold>: Indoleamine 2,3-dioxygenase-1 (IDO1) is a promising target for immunotherapy in bladder cancer (BC). IDO1 breaks-down tryptophan to generate kynurenine derivatives, which may activate the aryl hydrocarbon receptor (AHR). AHR is an important target for carcinogens, but its association with BC progression was unknown. Two IDO1 inhibitors used in clinical trials ar...

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Literature Corpus work: 7bde8f9d-df78-5483-8d08-cdf216a3d4aa
DOI: 10.21203/rs.3.rs-31922/v3

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