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The tryptophan–kynurenine pathway in immunomodulation and cancer metastasis

29 Aug 2023

Abstract excerpt

INTRODUCTION: The activation of the kynurenine pathway in cancer progression and metastasis through immunomodulatory pathways has drawn attention to the potential for kynurenine pathway inhibition. The activation of the kynurenine pathway, which results in the production of kynurenine metabolites through the degradation of tryptophan, promotes the development of intrinsically malignant properties in cancer cells...

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PMID: 37644823
DOI: 10.1002/cam4.6484

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