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Robust Mendelian Randomization Analysis by Automatically Selecting Valid Genetic Instruments with Applications to Identify Plasma Protein Biomarkers for Alzheimer’s Disease

2024-01-23

Abstract excerpt

<title>Abstract</title> <p>Mendelian randomization (MR) uses genetic variants as instrumental variables (IVs) to infer the causal effect of a modifiable exposure on the outcome of interest by removing unmeasured confounding bias. However, some genetic variants might be invalid IVs due to violations of core IV assumptions. MR analysis with invalid IVs might lead to biased causal effect estimate and misleading scie...

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Literature Corpus work
9f4174b3-ed77-503c-b9a7-03d81afb23d0
DOI
10.21203/rs.3.rs-3703437/v1
Open publication

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