Article
Obestatin attenuated doxorubicin-induced cardiomyopathy via enhancing long noncoding Mhrt RNA expression.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - 1 Jul 2016
Li Hong-Qi, Wu Yuan-Bo, Yin Chang-Sen, Chen Li, Zhang Qi, Hu Li-Qun
Abstract excerpt
OBJECTIVE: The emergence of side-effect of doxorubicin in cardiomyopathy and heart failure has led to the search for diverse strategies to prevent its cytotoxic effects. This study was to determine the role of obestatin on doxorubicin-induced cardiomyocytes apoptosis and possible underlying mechanism. METHODS: Sprague Dawley rats were divided into 3 groups and received treatment for a total of 6 weeks: group1,...
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