Article
Characterization of Skeletal Phenotype and Associated Mechanisms With Chronic Intestinal Inflammation in the Winnie Mouse Model of Spontaneous Chronic Colitis.
Inflammatory bowel diseases - 1 Feb 2022
Al Saedi Ahmed, Sharma Shilpa, Bani Hassan Ebrahim, Chen Lulu, Ghasem-Zadeh Ali, Hassanzadeganroudsari Majid, Gooi Jonathan H, Stavely Rhian, Eri Rajaraman, Miao Dengshun, Nurgali Kulmira, Duque Gustavo
Abstract excerpt
BACKGROUND: Osteoporosis is a common extraintestinal manifestation of inflammatory bowel disease (IBD). However, studies have been scarce, mainly because of the lack of an appropriate animal model of colitis-associated bone loss. In this study, we aimed to decipher skeletal manifestations in the Winnie mouse model of spontaneous chronic colitis, which carries a MUC2 gene mutation and closely replicates ulcerative...
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