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The monocyte-to-osteoclast transition in rheumatoid arthritis: Recent findings

12 Sept 2022

Abstract excerpt

Rheumatoid arthritis (RA) is an autoimmune disease characterized by joint inflammation leading to joint destruction and deformity. The crucial role of osteoclasts in the bone erosion in RA has been demonstrated. Deregulated osteoclastogenesis which is affected by environmental factors including the inflammatory state, as well as genetic and epigenetic factors, is one of hallmarks of RA pathogenesis. An...

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PMID: 36172385
DOI: 10.3389/fimmu.2022.998554

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