Article
Monocytic MDSCs skew Th17 cells toward a pro-osteoclastogenic phenotype and potentiate bone erosion in rheumatoid arthritis.
Rheumatology (Oxford, England) - 14 May 2021
Chen Shixian, Guo Chunqing, Wang Ran, Feng Zhitao, Liu Zheng, Wu Lisheng, Zhao Di, Zheng Songyuan, Chen Feilong, Zhang Dingding, Xu Juan, Zhu Junqing, Chen Xiaoguang, Li Zhanguo, Wise Christopher M, Li Juan, Wang Xiang-Yang
Abstract excerpt
OBJECTIVES: While myeloid-derived suppressor cells (MDSCs) were previously shown to promote a proinflammatory T helper (Th) 17 response in autoimmune conditions, a potential impact of the MDSC-Th17 immune axis on abnormal bone destruction in RA remains largely unknown. METHODS: We investigated the correlation between the frequency of MDSCs or its subsets and joint destruction in RA patients. The reciprocal...
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