Article

Skeletal Phenotype and Mechanisms of Bone Loss in <i>Winnie</i> Mice as a Model for Inflammatory Bowel Disease

2020-09-28

Abstract excerpt

<h4>Objective</h4> We aimed to investigate the skeletal phenotype of Winnie mouse model of spontaneous chronic colitis, which carries a mutation in the Muc2 gene and closely replicates IBD symptoms and pathophysiology. These mice have a high level of gut-derived serotonin (GDS), a potent osteoblastogenesis inhibitor. We explored the underlying mechanisms of bone loss associated with chronic intestinal inflammat...

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Literature Corpus work: 2b5a78c6-c827-5a04-9497-ca2560500ff0
DOI: 10.1101/2020.09.28.317495

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