Article

Primate-Specific LINC03040 Drives Myeloid-Dependent Fibrosis in Human MASH Through a STAT3–S100A8 Regulatory Axis

2026-02-27

Abstract excerpt

<title>Abstract</title> <p> Background While the recent approval of resmetirom marks a historic milestone in MASH therapy, the effective reversal of established cirrhosis (F4) remains a major unmet clinical need. A fundamental limitation in anti-fibrotic drug development is the profound translational gap between murine models and human immunopathology, particularly with respect to species-specific non-coding re...

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Literature Corpus work: 1cf18b0d-049f-500f-86bc-a09db522251d
DOI: 10.21203/rs.3.rs-8780157/v2

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