Article

An Integrated Single-Cell Atlas Reveals Hepatic Stellate Cell Heterogeneity and Spatiotemporal Dynamics after Liver Injury

2025-11-29

Abstract excerpt

<h4>Background</h4> Hepatic stellate cells (HSCs) orchestrate fibrosis-free repair after acute liver injury (ALI) and sustain fibrogenesis in chronic liver injury (CLI). However, the heterogeneity and spatiotemporal dynamics of HSCs across these different injury models remain elusive. This study sought to construct a cross-etiological HSC atlas to delineate HSC states and transitions during liver injury. <h4>Meth...

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Literature Corpus work: 76f37d51-42ea-503e-aa07-e8fcce2f2e80
DOI: 10.1101/2025.11.25.690307

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