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Article

The extracellular subunit interface of the 5-HT3 receptors: a computational alanine scanning mutagenesis study.

Journal of biomolecular structure & dynamics - 1 Jan 2012

De Rienzo Francesca, Barbosa Arménio J Moura, Perez Marta A S, Fernandes Pedro A, Ramos Maria J, Menziani Maria Cristina

Abstract excerpt

The functional serotonin 5-HT type-3 (5-HT(3)) receptor, the target of many neuroactive drugs, is known to be a pseudo-symmetric pentamer made either of five identical subunits A (homomeric 5-HT(3A)-R) or of subunits A and B (heteromeric 5-HT(3A/B)-R) in a still debated arrangement. The serotonin binding site is located in the extracellular region, at the interface between two monomers, called the principal and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22694192
DOI: 10.1080/07391102.2012.680029

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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