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Article

Transcriptional analysis of cleft palate in TGFβ3 mutant mice.

Scientific reports - 10 Sept 2020

Liu J, Chanumolu S K, White K M, Albahrani M, Otu H H, Nawshad A

Abstract excerpt

Cleft palate (CP) is one of the most common craniofacial birth defects, impacting about 1 in 800 births in the USA. Tgf-β3 plays a critical role in regulating murine palate development, and Tgf-β3 null mutants develop cleft palate with 100% penetrance. In this study, we compared global palatal transcriptomes of wild type (WT) and Tgf-β3 -/- homozygous (HM) mouse embryos at the crucial palatogenesis stages of...

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Share to Embryo, Mammalian
Share to Cleft Palate
Share to Epithelial-Mesenchymal Transition

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation

Share to Mice, Knockout

Share to RNA-Seq

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Share to Transforming Growth Factor beta3

Source

Open in PubMed Open full text

Identifiers

PMID: 32913205
DOI: 10.1038/s41598-020-71636-0
PMCID: PMC7483747

Genes

CP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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