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A Developmental Toxicology Assay Platform for Screening Teratogenic Liability of Pharmaceutical Compounds

5 Jan 2016

Abstract excerpt

Increasing need for proactive safety optimization of pharmaceutical compounds has led to generation and/or refinement of in vitro developmental toxicology assays. Our laboratory has developed three in vitro developmental toxicology assays to assess teratogenic liability of pharmaceutical compounds. These assays included a mouse molecular embryonic stem cell assay (MESCA), a dechorionated zebrafish embryo culture...

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PMID: 26729651
DOI: 10.1002/bdrb.21168

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