Article
Retinoic acid, GABA-ergic, and TGF-beta signaling systems are involved in human cleft palate fibroblast phenotype.
Molecular medicine (Cambridge, Mass.) - 1 Jan 2000
Baroni Tiziano, Bellucci Catia, Lilli Cinzia, Pezzetti Furio, Carinci Francesco, Becchetti Ennio, Carinci Paolo, Stabellini Giordano, Calvitti Mario, Lumare Eleonora, Bodo Maria
Abstract excerpt
During embryogenesis, a complex interplay between extracellular matrix (ECM) molecules, regulatory molecules, and growth factors mediates morphogenetic processes involved in palatogenesis. Transforming growth factor-beta (TGF-beta), retinoic acid (RA), and gamma-aminobutyric acid (GABA)ergic signaling systems are also potentially involved. Using [3H]glucosamine and [35S]methionine incorporation, anion exchange...
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