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Article

Association of valproate‐induced teratogenesis with histone deacetylase inhibition in vivo

18 May 2005

Abstract excerpt

Chemically induced birth defects are an important public health and human problem. Here we use Xenopus and zebrafish as models to investigate the mechanism of action of a well-known teratogen, valproic acid (VPA). VPA is a drug used in treatment of epilepsy and bipolar disorder but causes spina bifida if taken during pregnancy. VPA has several biochemical activities, including inhibition of histone deacetylases...

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PMID: 15901671
DOI: 10.1096/fj.04-3425fje

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