Article

Metagenomic analysis during capecitabine therapy reveals microbial chemoprotective mechanisms and predicts drug toxicity in colorectal cancer patients

2024-10-15

Abstract excerpt

<h4>Purpose</h4> Unpredictable chemotherapy side effects are a major barrier to successful treatment. Cell culture and mouse experiments indicate that the gut microbiota is influenced by and influences anti-cancer drugs. However, metagenomic data from patients paired to careful side effect monitoring remains limited. Herein, we focus on the oral fluoropyrimidine capecitabine (CAP). We investigate CAP-microbiome in...

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Literature Corpus work: 1c9ed8f9-79d7-5d95-9a95-cf462c661d75
DOI: 10.1101/2024.10.11.24315249

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