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Microbial vitamin biosynthesis links gut microbiota dynamics to chemotherapy toxicity

20 May 2025

Abstract excerpt

ABSTRACT Dose-limiting toxicities pose a major barrier to cancer treatment. While preclinical studies show that the gut microbiota influences and is influenced by anticancer drugs, data from patients paired with careful side effect monitoring remains limited. Here, we investigate capecitabine (CAP)-microbiome interactions through longitudinal metagenomic sequencing of stool from 56 advanced colorectal cancer...

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PMID: 40391895
DOI: 10.1128/mbio.00930-25

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