Article

Interrogating Mutant Allele Expression via Customized Reference Genomes to Define Influential Cancer Mutations

2018-08-17

Abstract excerpt

Genetic alterations are essential for cancer initiation and progression. However, differentiating mutations that drive the tumor phenotype from mutations that do not affect tumor fitness remains a fundamental challenge in cancer biology. To better understand the impact of a given mutation within cancer, RNA-sequencing data was used to categorize mutations based on their allelic expression. For this purpose, we dev...

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Literature Corpus work: 1c9e2983-b874-559d-a554-2eab92c9bef2
DOI: 10.1101/394627

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