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Article

Twelve-hour normothermic liver perfusion in a rat model: characterization of the changes in the ex-situ bio-molecular phenotype and metabolism.

Scientific reports - 13 Mar 2024

Dondossola Daniele, Lonati Caterina, Battistin Michele, Vivona Luigi, Zanella Alberto, Maggioni Marco, Valentina Vaira, Zizmare Laimdota, Trautwein Christoph, Schlegel Andrea, Gatti Stefano

Abstract excerpt

The partial understanding of the biological events that occur during normothermic machine perfusion (NMP) and particularly during prolonged perfusion might hinder its deployment in clinical transplantation. The aim of our study was to implement a rat model of prolonged NMP to characterize the bio-molecular phenotype and metabolism of the perfused organs. Livers (n = 5/group) were procured and underwent 4 h...

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Identifiers

PMID: 38472309
DOI: 10.1038/s41598-024-56433-3
PMCID: PMC10933381

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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