Article

Integrated Molecular Profiling of Preclinical and Clinical Cardiac Xenotransplants

2026-02-04

Abstract excerpt

<title>Abstract</title> <p>Heart failure remains a leading cause of death worldwide, and the persistent shortage of donor hearts limits allogeneic cardiac transplantation. Advances in porcine genome editing, immunosuppression, and virological testing have brought cardiac xenotransplantation - the implantation of genetically engineered porcine hearts into humans - to clinical stage. The two recent first-in-human c...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 25477d7d-c22a-5d89-ab77-88d4b3039834
DOI: 10.21203/rs.3.rs-8406985/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Integrated Molecular Profiling of Preclinical and Clinical Cardiac XenotransplantsDOI 10.21203/rs.3.rs-8406985/v1Read

Integrative Multi-omic Profiling of Two Human Decedents Receiving Pig Heart Xenografts Reveals Strong Perturbations in Early Immune-Cell and Cellular Metabolism ResponsesSemantic proximity Read

Changes in cardiac gene expression after pig‐to‐primate orthotopic xenotransplantationSemantic proximity Read

Longitudinal multi-omic profiling of a pig-to-human lung xenograft reveals phased immune and tissue-remodeling responsesSemantic proximity Read

Single-nuclear RNA sequencing of endomyocardial biopsies identifies persistence of donor-recipient chimerism with distinct signatures in severe cardiac allograft vasculopathySemantic proximity Read

Progress Toward Cardiac XenotransplantationSemantic proximity Read

Comparative transcriptome analysis between long- and short-term survival after pig-to-monkey cardiac xenotransplantation reveals differential heart failure developmentSemantic proximity Read

Dynamic responses to rejection in the transplanted human heart revealed through spatial transcriptomicsSemantic proximity Read

Endothelial PTBP1 Deletion in Transplanted Cardiac Tissue Limits Cardiac Allograft VasculopathySemantic proximity Read

Progressive Genetic Modifications with Growth Hormone Receptor Knockout Extends Cardiac Xenograft Survival to 9 MonthsSemantic proximity Read

Aging under immunosuppression reshapes human immune compartments and lowers clinical alloreactivity after heart transplantationSemantic proximity Read

Xenotransplantation Literature Update July–December 2024Semantic proximity Read

Graft-Induced Reprogramming Under Arterial Hemodynamic Stress is Associated with a Shared Proteomic Phenotype in Arterial and Venous Conduits Following Coronary Artery Bypass GraftingSemantic proximity Read